Izinto Okucatshangwa Ngazo Ngemithi Yendabuko YamaShayina (i-TCM)
| Isici Esiyinhloko | Izinto okufanele uzicabangele | Izinyathelo Zokulawula Ingozi |
| Ukwelashwa Kwamakhambi Ngaphambi Kokwelashwa | Okuqukethwe komswakama, okuqukethwe yifayibha/uwoyela | Lawula umswakama (ngokuvamile ≤10%); nquma amakhambi anemicu noma amafutha ngaphambi kokuba uwaqede uma kudingeka |
| Ukukhethwa Kwemishini | Izakhiwo zezitshalo (ubulukhuni, ukujiya, njll.) | Sebenzisa izigayo ze-hammer ukuze uthole amakhambi aqhekeka kalula, izigayo ze-shear noma ze-turbo ukuze uthole amakhambi ane-fibrous |
| Ukulawula Izinga Lokushisa | Ukukhiqizwa kokushisa okuholela ekulahlekelweni kwamakhemikhali asebenzayo | Ukuchoboza okushisa okuphansi (isb., ukupholisa amanzi), ukusebenza ngezikhathi ezithile; ukugaya okune-cryogenic (i-nitrogen ewuketshezi) kwamakhambi azwela ukushisa |
| Izidingo Zobunono | Izindinganiso zobukhulu bezinhlayiya zokusetshenziswa okuhlukene (isb. amaphilisi, izimpushana, izingcezu) | Lungisa i-seeve mesh (ngokuvamile i-80-200 mesh) ngokusekelwe ezidingweni zenqubo; gwema ukuchoboza ngokweqile okuphazamisa ukusebenza kahle |
| Ukuvimbela Uthuli Nokuqhuma | Izingozi ezivuthayo/eziqhumayo (isb., isitashi, uwoyela oshintshashintshayo) | Sebenzisa ama-motor angaqhumi, ukuvikela igesi engasebenzi, ukususa uthuli, kanye nezinyathelo zokulwa nokuma |
| Ukungcoliswa kwe-Microbial | Ama-microorganism avela kumakhambi noma endaweni ezungezile | Sebenza ezindaweni ezihlanzekile; faka imisebe noma ukubulala amagciwane uma kudingeka |
| Ukulawulwa Kokungcoliswa Kwensimbi | Izicucu zensimbi ezivela ekugugeni kwemishini | Ukuhlukaniswa kwamagnetic, ukuhlolwa okuvamile kwezisefo/ama-blade; beka phambili imishini yensimbi engagqwali |
| Ukufana Kwengxenye | Ukwehlukaniswa ngenxa yokwehluka kobuningi bamakhambi axubile | Ukuchoboza okunezigaba eziningi + ukuxuba, noma ukusebenzisa ubuchwepheshe be-composite homogenization |
| Ukungcoliswa Okuphambene | Izinkomba ezisele phakathi kwamakhambi ahlukene | Izinqubo zokuhlanza eziqinile, ukufaka ikhodi yombala, noma imigqa yokukhiqiza enikezelwe |
| Ukulondolozwa Kwamakhemikhali Aguquguqukayo | Amakhambi anephunga elimnandi (isb., i-mint, i-borneol) | Ukuchoboza okuvaliwe, ukucubungula okusheshayo okushisa okuphansi ukuze kuncishiswe ukuvezwa |
Amaphuzu Abalulekile Okulawula Inqubo Ngesikhathi Sokukhiqizwa Kwe-Sodium Deoxycholate
| Isinyathelo | Amapharamitha Okulawula | Ukunciphisa Ingozi |
| I-Hydrolysis | Ukuhlushwa kwe-NaOH, izinga lokushisa, isikhathi | Gwema ukuhlanza ngokweqile ukuze uvimbele ukukhiqizwa kokungcola |
| Ukuna kwe-asidi | i-pH (ngokuqinile 3-4), izinga lokupholisa | Vimbela ukuhlanganiswa kwe-emulsification noma ukungcola okubambekayo ezinhlakeni |
| Ukususwa komoya-mpilo | Umsebenzi we-Catalyst, umthamo we-H₂ pressure/we-ejenti yokunciphisa | Iphuzu lokugcina lokusabela kwe-Monitor (TLC/HPLC) |
| Ukuvuselelwa kabusha | Isilinganiso se-solvent, izinga lokushisa lokususa umbala | Sebenzisa ikhabhoni esebenzayo yezinga lemithi ukuze ugweme izinsalela zensimbi esindayo |
| Ukwakheka kukasawoti | Ukulawulwa kwe-pH okunembile (8-9) | Vimbela ukwenziwa ngokweqile kwe-alkalization endaweni okuholela ekuwohlokeni |
| Ukomisa | Izinga lokushisa ≤60℃, izinga le-vacuum | Gwema ukubola noma ukuhlangana kwezingxenye ezizwela ukushisa |
Sizibophezele ngokuqinile endleleni eqhutshwa kabili ehlanganisa izinhlelo zokuphatha ze-GMP kanye ne-ISO, ehlanganisa ukuphepha, ukuvikelwa kwemvelo kanye nokusungula izinto ezintsha njengezimiso zethu eziyisisekelo. Lokhu kumelela indlela yethu yesayensi yokuthuthukisa ukuncintisana okuyinhloko nokufeza intuthuko esimeme.
Uhlu Lwemishini Yokukhiqiza Engaphelele:
Ithangi lokukhipha, ikholomu yokukhipha, i-centrifuge, i-concentrator, uhlelo lokukhipha olusebenzisa i-counter-current, i-homogenizer, i-UHT sterilizer, i-spray dryer, i-microwave dryer, i-mixer, njll.
Xhumana Nathi
Uma udinga ulwazi olwengeziwe ngezinqubo zokukhiqiza kanye nezinsizakalo ezenziwe ngokwezifiso, sicela ukhululeke ukuxhumana nethimba lethu lochwepheshe nganoma yisiphi isikhathi.