I-Berberine Hydrochloride
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Ulwazi Oluyisisekelo
Igama Lomkhiqizo: I-Berberine Hydrochloride
Igama Lekhemikhali:5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride
Ifomula Yamamolekyuli: C₂₀H₁₈ClNO₄
Inombolo ye-CAS:【 633-65-8】
Isisindo sama-molecule: 372.822
Ukuncibilika: Incibilika kalula emanzini abilayo, incibilika kancane emanzini abandayo, futhi cishe ayincibiliki ku-ethanol ebandayo, i-chloroform, kanye ne-ether
Izinga Lekhwalithi: I-CP2020, JP, Kwenziwe Amakhasimende
Imininingwane
Izinto Zokuhlola | Okujwayelekile |
I-Berberine Hydrochloride 【633-65-8】 | ≥97.0% nge-HPLC |
Ukulahlekelwa ekomiseni | ≤12.0% |
Izinsalela ezivuthayo | ≤0.2% |
Izici Eziyinhloko
Izinzuzo Ezinemisebenzi Eminingi
Ukulawulwa Kwe-Metabolic: Isebenzisa izindlela ze-AMPK ukusekela ukuphathwa koshukela kanye nama-lipid egazini, okulungele abantu abanesifo sikashukela noma ukukhuluphala ngokweqile.
I-Antimicrobial kanye ne-Anti-inflammatory: Ivimbela amagciwane anjenge-E. coli kanye ne-Staphylococcus aureus, isiza ekuthelelekeni kwamathumbu.
Impilo Yamathumbu: Iguqula i-intestinal microbiota, inciphise uhudo kanye nokungagayeki kahle kokudla.
Imvelaphi Yemvelo
Kuvela kumakhambi ezokwelapha, kuhlanganisa ukusebenza kahle kwendabuko nokuqinisekiswa kwesayensi.
Ukuhlanzeka Okuphezulu
Ukuhlanzwa okuthuthukisiwe kuqinisekisa ubumsulwa obungu-≥98% ukuze kusebenze kahle futhi kuzinze.
i-antibacterial ye-spectrum yomgwaqo
Ilwa namagciwane ahlukahlukene e-Gram-positive ne-Gram-negative (isb. i-Shigella, i-Escherichia coli, i-Staphylococcus aureus, i-Hemolytic streptococcus, i-pneumococcus, i-typhoid bacilli, njll.)
Imiphumela yezokwelapha Okuphezulu okuluhlaza okotshani
I-Berberine hydrochloride inomphumela we-antibacterial we-spectrum ebanzi, futhi indlela yayo yokusebenza ihlanganisa ikakhulukazi:
1. Kuphazamisana nokuguqulwa kwe-bacterial metabolism: Kuvimbela inqubo ye-oxidation kanye ne-decarboxylation ye-pyruvate, okuyisixhumanisi esiphakathi kukuguqulwa kwe-bacterial sugar metabolism.
2. Vimbela ukuphindaphindeka kwe-DNA yamagciwane Kuthinta i-metabolism ye-nucleic acid yamagciwane futhi kuphazamise ukwakheka kwezinto zawo zofuzo.
3. Ukulimala kwesakhiwo samagciwane: Kunomphumela olimazayo olwelwesini lweseli lwamagciwane futhi kuthinta umsebenzi wawo wokuvimbela.
4. Ukulawulwa kokulwa nokuvuvukala kanye nokuzivikela komzimba: Kunomphumela othile wokulwa nokuvuvukala futhi kunganciphisa izimpendulo zokuvuvukala kwamathumbu; Ezinye izifundo zikhombisa nokuthi kunomphumela wokulawula ukusebenza kokuzivikela komzimba kwamathumbu.
5. I-Astringent kanye ne-antidiarrhea: Inomthelela we-astringent ku-mucosa yamathumbu futhi inciphisa ukukhiqizwa koketshezi lwamathumbu.
Isilinganiso Nokuphathwa
1. Abantu abadala: 100–300 mg, izikhathi ezingu-2–3 ngosuku ngemva kokudla (xhumana nodokotela ukuze uthole umthamo oqondile).
2. Izimo zokuphikisana: Akuyona eyabesifazane abakhulelwe noma iziguli ezine-hemolytic jaundice; gwema ukusebenzisa kanyekanye nemithi ye-hypoglycemic noma ama-antibiotic (kudingeka ukubhekwa ngudokotela).
Iphrofayili Yokuphepha
Izifundo zezokwelapha zibonisa imiphumela emibi emincane (isb., ukuqunjelwa ngezikhathi ezithile noma ukuqunjelwa) ngemithamo enconywayo, ngaphandle kobuthi be-hepatorenal. Ukusetshenziswa kwesikhathi eside kufanele kufake ukuqapha impilo njalo.
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